Vasculoprotective effects of somatostatin receptor subtypes
نویسندگان
چکیده
منابع مشابه
Somatostatin receptor subtypes in human immune cells.
Somatostatin is a neuropeptide hormone that is widely distributed throughout the body. It was first discovered as a factor inhibiting the release of growth hormone. Later it was shown to have many functions in the endocrine system including the inhibition of secretion of other pituitary hormones, in addition to that of gastrointestinal hormones. Moreover, somatostatin acts as a neurotransmitter...
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Although in situ hybridization has been used to examine the distribution of messenger RNA for somatostatin receptor subtypes (sst) in human tumors, the cellular localization of sst1 and sst2A receptors has not been reported. In this study, we describe the cellular localization of human sst1 and sst2A receptor proteins in both cryostat- and paraffin-embedded sections of 25 human tumor tissues us...
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A variety of human neuroendocrine tumours express SSTR. The five recently cloned human SSTR subtypes have a distinct chromosomal localization and pharmacological profile, and a tissue-specific expression pattern which suggests a differential function of SSTR subtypes in different organ systems. Most tumours carrying SSTR may express multiple SSTR subtypes, while the SSTR2 subtype is most predom...
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The tetradecapeptide somatostatin has been implicated as an important regulator of neuronal and neuroendocrine function in the CNS. The cellular actions of somatostatin are mediated by specific receptors. The genes encoding two different somatostatin receptors (SSTRs) have been isolated and characterized, and RNA blotting studies have shown that both SSTR1 and SSTR2 are expressed in the brain. ...
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1. Growth hormone (GH) secretion from pituitary somatotropes is mainly regulated by two hypothalamic hormones, GH-releasing hormone (GHRH) and somatotrophin releasing inhibitory factor (SRIF). 2. Somatotrophin releasing inhibitory factor inhibits GH secretion via activation of specific membrane receptors, somatostatin receptors (SSTRs) and signalling transduction systems in somatotropes. 3. Fiv...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2007
ISSN: 0303-7207
DOI: 10.1016/j.mce.2007.08.018